Description of graphic titled: AHS Study Overview

This graphic shows five boxes above a timeline, each representing a phase in the AHS Study

• Enrollment (1993-1997)
  • Pesticide applicators recruited at training
  • Spouses of farmer applicators
  • Detailed pesticide history
• Phase 2 (1999-2003)
  • Follow-up questionnaire
  • Update pesticide use and medical history
  • Diet questionnaire
  • Buccal cell collection
• Phase 3 (2005-2010)
  • Follow-up questionnaire
  • Update pesticide use and medical history
• Phase 4 (2013-2015)
  • Follow-up questionnaire
  • Update farming status and medical history
• Phase 5 (2019-2021)
  • Follow-up questionnaire
  • Update farming status and medical history

The timeline spans from 1993 to 2023 and has three arrow shapes beneath it.

• Spanning from approximately 1993 to 2023
  • Regular linkages to cancer and mortality registries*
• Spanning from approximately 1999 to 2017
  • Linkages to identify end-stage renal disease**
• Spanning from approximately 1999 to 2016
  • Linkages to identify Medicare claims data**

Footnote

The cohort is also followed for mortality, cancer incidence, end stage renal disease incidence, and other incidence diseases through periodic linkage with state cancer registries*, the National Death Index (NDI)*, and the United States Renal Data System (USRDS)** and Medicare claims data**.