Add-on Studies

Data and samples from add-on studies are made available to outside collaborators on a case-by-case basis. Information on what was collected and what may be available for new investigations can be obtained by contacting the study PI or the AHS lead investigator.

Farming and Movement Evaluation Study (FAME)

PI: Caroline Tanner, The Parkinson’s Institute
AHS EC Contact: Dale Sandler, NIEHS

The Farming and Movement Evaluation (FAME) study is a case-control study of Parkinson’s Disease nested within the AHS. Home visits were conducted to perform structured neurologic examinations, draw blood, and collect dust. PD diagnoses were confirmed by movement disorder specialists. 115 confirmed PD cases and 383 controls were included in this study which was funded by an R01 grant to Dr. Tanner, supplemented with NIEHS Intramural Program funds.

Neurobehavioral Testing Study

PI: Fred Gerr, University of Iowa
AHS EC Contact: Dale Sandler, NIEHS

This study, funded through an R01 grant to Dr. Gerr, was designed to assess the impact of chronic low level pesticide exposure on neurobehavioral function. Neurobehavioral testing was conducted on 701 farmers in the AHS from Nov 2006-March 2008. Participants were selected based on their lifetime use of organophosphate insecticides; individuals with the greatest use were oversampled to allow better representation of the high end of the exposure distribution. At the time of testing, a questionnaire was administered and blood was drawn for genetic and other analyses.

Growth and Puberty Study

PI: Michele Marcus, Emory
AHS EC Contact: Dale Sandler, NIEHS

The Growth and Puberty Study is a pilot study to validate early markers of puberty and to evaluate the influence of agricultural exposures on pubertal growth and development involving farm families within a 100 mile radius of Des Moines, IA. Families of children aged 7-15 were invited to participate. Children were asked to provide urine and saliva samples at each of three study visits three months apart. At each visit, height, weight and fat free body mass were measured and questionnaires on Tanner staging were completed by adults and children. 48 families representing 77 children participated.

Lung Health Study

PI: Stephanie London, NIEHS
AHS EC Contact: Dale Sandler, NIEHS

The Lung Health Study is a case-cohort study of current asthma in the AHS conducted from 2009 to 2013. Cases were identified based on responses to the Phase 3 follow-up interview; the sub-cohort is a random sample of all individuals who completed the Phase 3 interview. More than 3,000 AHS participants completed home visits that included lung function tests, height and weight measurement, and collection of blood, urine, and dust samples. Participants also completed a telephone interview about their history of respiratory diseases and lifetime farm exposures.

Biomarkers of Exposure and Effects in Agriculture (BEEA)

PI: Jon Hofmann, NCI
AHS EC Contacts: Jon Hofmann, NCI

The BEEA study was designed to investigate the biologic plausibility and potential mechanisms of action through which agricultural exposures influence risk of cancer and other chronic diseases. Biospecimens, including blood, urine, and buccal cells, as well as house dust samples and updated information on pesticide use and other agricultural exposures were collected from 1,681 male AHS farmer/applicators and 211 demographically similar unexposed controls enrolled between 2010-2018.